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2006 1
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2008 5
2009 6
2010 10
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2012 14
2013 15
2014 15
2015 14
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2019 21
2020 22
2021 23
2022 16
2023 14
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205 results

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Page 1
Prolonged indoleamine 2,3-dioxygenase-2 activity and associated cellular stress in post-acute sequelae of SARS-CoV-2 infection.
Guo L, Appelman B, Mooij-Kalverda K, Houtkooper RH, van Weeghel M, Vaz FM, Dijkhuis A, Dekker T, Smids BS, Duitman JW, Bugiani M, Brinkman P, Sikkens JJ, Lavell HAA, Wüst RCI, van Vugt M, Lutter R; Amsterdam UMC COVID-19 Biobank study Group. Guo L, et al. EBioMedicine. 2023 Aug;94:104729. doi: 10.1016/j.ebiom.2023.104729. Epub 2023 Jul 26. EBioMedicine. 2023. PMID: 37506544 Free PMC article.
The abundant expression of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase-2 (IDO2) in fatal/severe COVID-19, led us to determine, in an exploratory observational study, whether IDO2 is expressed and active in PASC, …
The abundant expression of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase-2 (IDO2) …
Indoleamine 2,3-dioxygenase 2 (IDO2) and the kynurenine pathway: characteristics and potential roles in health and disease.
Fatokun AA, Hunt NH, Ball HJ. Fatokun AA, et al. Amino Acids. 2013 Dec;45(6):1319-29. doi: 10.1007/s00726-013-1602-1. Epub 2013 Oct 9. Amino Acids. 2013. PMID: 24105077 Review.
Three enzymes are now known to catalyze the first and rate-limiting step in the catabolism of tryptophan along this pathway: tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO, subsequently named IDO1), both of w …
Three enzymes are now known to catalyze the first and rate-limiting step in the catabolism of tryptophan along this pathway: tryptophan 2 …
The role of indoleamine 2,3-dioxygenase 1 in early-onset post-stroke depression.
Chen H, Huang X, Zeng C, Sun D, Liu F, Zhang J, Liao Q, Luo S, Xu W, Xiao Y, Zeng D, Song M, Tian F. Chen H, et al. Front Immunol. 2023 Feb 24;14:1125634. doi: 10.3389/fimmu.2023.1125634. eCollection 2023. Front Immunol. 2023. PMID: 36911716 Free PMC article.
METHODS: According to Diagnostic and Statistical Manual of Mental Disorders (5th edition), depressive symptoms were assessed at 2 weeks after stroke onset. 15 single nucleotide polymorphisms (SNPs) in genes of indoleamine 2,3-dioxygenase (IDO, i …
METHODS: According to Diagnostic and Statistical Manual of Mental Disorders (5th edition), depressive symptoms were assessed at 2 wee …
Indoleamine 2,3-Dioxygenase 1: A Promising Therapeutic Target in Malignant Tumor.
Song X, Si Q, Qi R, Liu W, Li M, Guo M, Wei L, Yao Z. Song X, et al. Front Immunol. 2021 Dec 23;12:800630. doi: 10.3389/fimmu.2021.800630. eCollection 2021. Front Immunol. 2021. PMID: 35003126 Free PMC article. Review.
The degradation of tryptophan into immunosuppressive kynurenine is considered an important immunosuppressive mechanism in the tumor microenvironment. There are three enzymes, namely, tryptophan 2,3-dioxygenase (TDO), indoleamine 2,3-di …
The degradation of tryptophan into immunosuppressive kynurenine is considered an important immunosuppressive mechanism in the tumor microenv …
Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond.
Platten M, Nollen EAA, Röhrig UF, Fallarino F, Opitz CA. Platten M, et al. Nat Rev Drug Discov. 2019 May;18(5):379-401. doi: 10.1038/s41573-019-0016-5. Nat Rev Drug Discov. 2019. PMID: 30760888 Review.
Imbalances in Trp metabolism in disorders ranging from cancer to neurodegenerative disease have stimulated interest in therapeutically targeting the KP, particularly the main rate-limiting enzymes indoleamine-2,3-dioxygenase 1 (IDO1), IDO2 and t …
Imbalances in Trp metabolism in disorders ranging from cancer to neurodegenerative disease have stimulated interest in therapeutically targe …
Indoleamine 2,3-Dioxygenase 2 Deficiency Exacerbates Imiquimod-Induced Psoriasis-Like Skin Inflammation.
Fujii K, Yamamoto Y, Mizutani Y, Saito K, Seishima M. Fujii K, et al. Int J Mol Sci. 2020 Aug 1;21(15):5515. doi: 10.3390/ijms21155515. Int J Mol Sci. 2020. PMID: 32752186 Free PMC article.
Indoleamine 2,3-dioxygenase 1 (IDO1) is an enzyme known to suppress immune responses, and several reports have showed that it is associated with psoriasis. ...The expression of IDO2 in immune cells suggests that IDO2 may contribute to imm …
Indoleamine 2,3-dioxygenase 1 (IDO1) is an enzyme known to suppress immune responses, and several reports have s …
Indoleamine 2,3-dioxygenase (IDO)-1 and IDO-2 activity and severe course of COVID-19.
Guo L, Schurink B, Roos E, Nossent EJ, Duitman JW, Vlaar AP, van der Valk P, Vaz FM, Yeh SR, Geeraerts Z, Dijkhuis A, van Vught L, Bugiani M, Lutter R; also on behalf of the Amsterdam UMC COVID-19 Biobank Study Group. Guo L, et al. J Pathol. 2022 Mar;256(3):256-261. doi: 10.1002/path.5842. Epub 2022 Jan 10. J Pathol. 2022. PMID: 34859884 Free PMC article.
This was not related to the expression of the tryptophan-catabolizing indoleamine 2,3-dioxygenase (IDO)-1, but rather to that of its isoform IDO-2, which otherwise is expressed rarely. ...Markers of apoptosis and severe cellular stress were asso …
This was not related to the expression of the tryptophan-catabolizing indoleamine 2,3-dioxygenase (IDO)-1, but r …
Indoleamine 2,3-dioxygenase 2 deficiency associates with autism-like behavior via dopaminergic neuronal dysfunction.
Ishikawa M, Yamamoto Y, Wulaer B, Kunisawa K, Fujigaki H, Ando T, Kimura H, Kushima I, Arioka Y, Torii Y, Mouri A, Ozaki N, Nabeshima T, Saito K. Ishikawa M, et al. FEBS J. 2024 Mar;291(5):945-964. doi: 10.1111/febs.17019. Epub 2024 Jan 2. FEBS J. 2024. PMID: 38037233
Indoleamine 2,3-dioxygenase 2 (IDO2) is an enzyme of the tryptophan-kynurenine pathway that is constitutively expressed in the brain. To provide insight into the physiological role of IDO2 in the brain, behavioral and neurochemical …
Indoleamine 2,3-dioxygenase 2 (IDO2) is an enzyme of the tryptophan-kynurenine pathway that is con …
Indoleamine 2, 3-Dioxygenase: A Professional Immunomodulator and Its Potential Functions in Immune Related Diseases.
Heidari F, Ramezani A, Erfani N, Razmkhah M. Heidari F, et al. Int Rev Immunol. 2022;41(3):346-363. doi: 10.1080/08830185.2020.1836176. Epub 2020 Oct 29. Int Rev Immunol. 2022. PMID: 33118843 Review.
Indoleamine 2, 3-dioxygenase (IDO) as an intracellular cytosolic enzyme converts tryptophan (Trp) to N-formyl kynurenine which leads to proinflammatory T-cell apoptosis and prevention of immune cells maturation via decreasing the level of cellular ener …
Indoleamine 2, 3-dioxygenase (IDO) as an intracellular cytosolic enzyme converts tryptophan (Trp) to N-formyl ky …
205 results